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NB: The information displayed below does not replace the protocol. The latest protocol version should always be consulted before making clinical decisions.
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PICRAM 2
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Post-Intensive Care Risk-adjusted Alerting and Monitoring (PICRAM Phase 2)
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Topic
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Generic Relevance & Cross Cutting Themes
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Portfolio Eligibility
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Automatically eligible
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ISRCTN
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EudraCT
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MREC N°
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12\SC\0357
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UKCRN ID
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12730
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WHO ID
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Research Summary
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Patients discharged from intensive care units (ICU) have a very high risk of subsequently deteriorating on hospital wards. PICRAM will develop ways of alerting clinicians to these deteriorations early. After ICU discharge, there is little information available about the normal course which patients’ vital signs follow if they are safely discharged from hospital. Using an ambulatory monitor we plan to continuously record vital signs from up to 500 patients who have spent more than three days in ICU from 2 hospitals (one teaching hospital – Oxford University Hospitals NHS Trust one large district general hospital – The Royal Berkshire NHS Trust). We will also recover vital signs from the 72 hours leading up to discharge from the ICU, (recorded in the standard clinical electronic database). These two sets of data will allow us to understand the patterns by which patient recovery is displayed in vital signs. We will develop ways by which clinicians can be alerted to patients who are not following these patterns of recovery, as these patients will be at greater risk of deterioration. Finally, we will recover data from the patient’s ICU stay. We have developed a large anonymised database from the standard clinical electronic databases of the two Intensive Care Units. We are using this to design tools to help clinicians recognise which patients are at risk of deterioration after discharge from intensive care. We will use data from the Intensive Care Unit stay of the patients whose vital signs we record after intensive care discharge to work out how best to merge the data from their time in Intensive Care with the vital signs recovery patterns to best identify patients who are deteriorating after ICU discharge.
The use of prolonged ambulatory vital sign monitoring in post-intensive care patients is relatively novel. We will therefore record patients’ views on the wearability of the system and data on the functionality of the system.
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Study Type
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Observational
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Design Type
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Cohort study
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Disease(s)
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Critical Care
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Phase
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Pilot/Feasibility
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Current Status
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Open
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Closure Date
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11/22/2014
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Global Sample Size
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500
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Global Recruitment to Date
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 1% |
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Geographical Scope
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UK Multi-Centre
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Lead Country
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England
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Open to new sites
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No
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Main Inclusion Criteria
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1. Participant is willing and able to give informed consent for participation in the study.
2. Aged 16 years or above.
3. Discharged from adult intensive care unit.
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Main Exclusion Criteria
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1. Patients discharged for palliative care.
2. Patients whose anatomy, condition or prior surgery precludes the use of the wearable monitoring equipment.
3. Patients who cannot understand written English and for whom no translator can be found.
4. Patients not able to give informed consent due to diminished capacity.
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Chief Investigator(s)
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| Dr Duncan Young |
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Further details, please contact
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Ms Julie Darbyshire
John Radcliffe Hospital
Kadoorie Centre for Critical Care Research
Level 3
Headley Way
Headington
Oxford
Oxfordshire
OX3 9DU
UNITED KINGDOM
picram@ndcn.ox.ac.uk
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| Funder(s) |
Wellcome Trust
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| Sponsor(s) |
University of Oxford
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