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UKCRN Study Portfolio > Haematology


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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 AAV Antibodies in UK cohort of Haemophilia A Patients - Adenovirus-Associated Antibodies in UK cohort of Haemophilia A Patients: A seroprevalence study of the presence of Adenovirus-Associated Virus Vector–serotypes AAV2, AAV5 and AAV8 neutralizing activity and antibodies in Patients with Haemophilia AOpenObservationalNo
 ACIT - Activation of Coagulation and Inflammation in Trauma IIOpenObservationalYes, within and outside lead country
15490813Affinitie: Two cluster RCTs to evaluate feedback in blood transfusion audits - Affinitie: Two linked cluster randomised trials to evaluate feedback interventions embedded within a national audit of blood transfusion practiceOpenInterventional and ObservationalYes, within and outside lead country
 Anthem 1 - Nurse Facilitated Adherence Therapy for Haemophilia (AnTHem Trial) –A Cluster Randomised Controlled TrialOpenInterventional and ObservationalYes, within lead country only
 Bleeding disorders in women undergoing surgery for menorrhagia - Disorders of Platelet Function and Coagulation in Women Undergoing Surgical Intervention for Severe MenorrhagiaOpenObservationalNo
 BOOST - Biological Correlates of outcomes from Stem Cell Transplant - BOOST - Biological Correlates of outcomes from Stem Cell TransplantOpenObservationalNo
 BRIDGE-BPD - Genetic analysis of inherited platelet conditionsOpenObservationalNo
 CCRN 1070 (Stroke AF) - GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial Fibrillation (Phase II/III – EU/EEA Member States)OpenObservationalNo
 CCRN 2236 (Reversal agent bleeding) - A Phase III, case series clinical study of the reversal of the anticoagulant effects of dabigatran by intravenous administration of 5.0 g idarucizumab (BI 655075) in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.OpenInterventionalNo
 CCRN 2492 (Sickle cell and anaemia) - The efficacy and safety of Ferriprox® for the treatment of transfusional iron overload in patients with sickle cell disease or other anaemiasOpenInterventionalNo
 CCRN 2622 (Haemophilia patients undergoing surgery) - A Phase 3, Multi-Center, Open Label Study of Efficacy and Safety of PEGylated rFVIII (BAX 855) in Previously Treated Patients With Severe Hemophilia A Undergoing Surgical or Other Invasive ProceduresOpenInterventionalNo
 CCRN 2939 (Haemophilia) - A Phase 1 Single-ascending and Multiple-ascending Dose, Safety, Tolerability and Pharmacokinetics Study of Subcutaneously Administered ALN-AT3SC in Healthy Adult Volunteers and Hemophilia A or B Patients (Moderate or Severe Hemophilia)OpenInterventionalNo
 CCRN 2979 (Haemophilia A) - A Phase 3b Continuation study of the Safety and Efficacy of PEGylated Recombinant Factor VIII (PEG-rFVIII; BAX 855) in Prophylaxis of Bleeding in Previously Treated Patients with Severe Hemophilia AOpenInterventionalNo
 CCRN 3064 (Chronic Immune Thrombocytopenic Purpura) - A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Persistent/Chronic Immune Thrombocytopenic PurpuraOpenInterventionalNo
 CCRN 3248 (Thromboembolism) - Reduced-dosed rivaroxaban and standard-dosed rivaroxaban versus ASA in the longtermprevention of recurrent symptomatic venous thromboembolism in patients withsymptomatic deep-vein thrombosis and/or pulmonary embolismThe Einstein Choice StudyOpenInterventionalNo
 CCRN 757 (Haemophilia A) - EFFICACY AND SAFETY OF N8-GP DURING SURGICAL PROCEDURES IN PATIENTS WITH HAEMOPHILIA AOpenInterventionalNo
 CCRN 767 (Hemophilia A) - An Open-Label, Multicenter Evaluation of the Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor VIII Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia AOpenInterventionalNo
 Cellular immunity to herpesvirus infection: Studies with EBV & CMV -v1 - Cellular immunity to herpesvirus infection: Studies with Epstein-Barr virus and human cytomegalovirusOpenObservationalNo
 Characterisation of Paediatric Myelodysplasic Syndromes - Phenotypic and Genotypic Characteristics of Paediatric Myelodysplastic SyndromesOpenObservationalYes, within lead country only
 Cohort study investigating haemophilic arthropathy development V0.01 - Evaluation of the Effect of Musculoskeletal and Exercise Factors on the Development of Joint Disease in Haemophilia.OpenObservationalYes, within lead country only
 DEferiprone Evaluation in Paediatrics - Multicentre, randomised, open label, non-inferiority active-controlled trial to evaluate the efficacy and safety of deferiprone compared to deferasirox in paediatric patients aged from 1 month to less than 18 years affected by transfusion-dependent haemoglobinopathiesOpenInterventionalYes, within and outside lead country
 DVT natural history, recurrence and PTS - The response of lower limb deep vein thrombosis to anticoagulation therapy: resolution, recurrence and post thrombotic syndrome.OpenObservationalNo
67540073E-FIT 1 v1.0 - A multi-centre, randomised, double blind, placebo-controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage. E-FIT 1 StudyOpenInterventionalYes, within and outside lead country
 Faecal Microflora in ITP vs1 - Is Immune thrombocytopaenic purpura (ITP) associated with an abnormal faecal microflora?OpenObservationalYes, within lead country only
 Follow-up in Rivaroxaban patients in setting of thromboembolism - FIRST Registry: Follow-up in Rivaroxaban Patients in the Setting of ThromboembolismOpenObservationalYes, within lead country only
 GARFIELD-VTE - Global Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real worldOpenObservationalNo
77951167Genotyping and platelet phenotyping (GAPP) - Mild bleeding disorders caused by platelet defectsOpenObservationalYes, within lead country only
 GRAPHICS - Genetic Regulators and Platelets in Cardiac SurgeryOpenObservationalNo
23537803HA-1 Heterologous Prime Boost Vaccine Study - A phase I clinical trial of the vaccination of healthy human volunteers against the minor histocompatibility antigen (mHAg) HA-1 using a DNA and MVA 'prime/boost' regimenOpenInterventionalNo
 HAEM 3426 (CITP) - A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Persistent/Chronic Immune Thrombocytopenic PurpuraOpenInterventionalNo
 HAEM 3662 - A PHASE 1B, RANDOMISED, DOUBLE-BLIND (SPONSOR OPEN), PLACEBO CONTROLLED STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF 04447943, CO-ADMINISTERRED WITH AND WITHOUT HYDROXYUREA IN SBJECTS WITH STABLE SICKLE CELL DISEASEOpenInterventionalNo
 HAEM 3802 - Open Label, Adaptive Design, Ascending, Multiple-Dose Study to Evaluate Safety and Efficacy of BMS-986004 (Anti-CD40L dAb) in Adult Subjects with Primary Immune Thrombocytopenia (ITP)OpenInterventionalNo
 HAEM 3823 - A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hematopoietic Cell Transplant (HCT) Recipients with Respiratory Syncytial Virus (RSV) Infection of the Upper Respiratory TractOpenInterventionalNo
 HAEM 3911 (Von Willebrand Disease) - A PHASE 3 PROSPECTIVE, MULTICENTER STUDY TO EVALUATE EFFICACY AND SAFETY OF rVWF WITH OR WITHOUT ADVATE IN ELECTIVE SURGICAL PROCEDURES IN SUBJECTS WITH SEVERE VON WILLEBRAND DISEASE.OpenInterventionalNo
 HAEM 3929 - A prospective, international, longitudinal, observational disease registry of patient-reported outcomes (PROs), and the association with Hemophilia A and its treatment in patients with moderate to severe Hemophilia AOpenObservationalNo
 HAEM 4006 - A multi-centre, randomised, placebo controlled, double blinded, multiple dose trial investigating safety, pharmacokinetics and pharmacodynamics of concizumab administrated subcutaneously to haemophilia A subjects.OpenInterventionalNo
 HAEM 4033 - A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hematopoietic Cell Transplant (HCT) Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory TractOpenInterventionalNo
 HAEM 4174 - A Phase I randomised, placebo-controlled, double-blind, single and multiple ascending dose study of the tolerability and pharmacokinetics of GBT440 in healthy subjects and patients with Sickle Cell DiseaseOpenInterventionalNo
 HAEM 4448 - A Phase 1/2, Dose-Escalation Safety, Tolerability and Efficacy Study of BMN 270, an Adenovirus-Associated Virus Vector–Mediated Gene Transfer of Human Factor VIII in Patients with Severe Haemophilia AOpenInterventionalNo
 HAEM 4456 - Comparative Testing of Caltag Medsystems' TransFix/EDTA Vacuum Blood Collection Tubes (TVTs) and Streck Cyto-Chex Blood Collection Tubes (BCTs)OpenInterventionalNo
 HAEM 4735 ALN-AT3SC-002_Extension study - AN OPEN-LABEL EXTENSION STUDY OF SUBCUTANEOUSLY ADMINISTERED ALN-AT3SC IN PATIENTS WITH MODERATE OR SEVERE HAEMOPHILIA A OR B WHO HAVE PARTICIPATED IN A PREVIOUS CLINICAL STUDY WITH ALN-AT3SCOpenObservationalNo
 HAEM 4794 - A Phase 2, Open Label, Randomised, Dose Ranging, Safety, Efficacy, Pharmacokinetic and Pharmacodynamic Study of AG348 in Adult Patients with Pyruvate Kinase DeficiencyOpenInterventionalNo
 HAEM 4806 HESTIA2 - A randomised, double-blind, double-dummy, parallel-group, multicenter, phase IIb study to evaluate the effect of ticagrelor 10 mg and 45 mg bid versus placebo in reducing the number of days with pain in young adults with sickle cell diseaseOpenInterventionalNo
 HAEM 5344 - Long-term Safety and Efficacy Study of Ferriprox® for the Treatment of Transfusional Iron Overload in Patients with Sickle Cell Disease or Other AnaemiasOpenInterventionalNo
 HAEM3406 (997HA306) - An Open-Label, Multicenter Evaluation of the Safety and Efficacy of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc; BIIB031) in the Prevention and Treatment of Bleeding in Previously Untreated Patients With Severe Hemophilia AOpenInterventionalNo
 HAEM3579 (20101221) - A Single Arm, Open-label, Long-term Efficacy and Safety Study of Romiplostim in Thrombocytopenic Pediatric Subjects With Immune Thrombocytopenia (ITP)OpenInterventionalNo
 HAEM3709 (D5136C00007) - Multicenter, open-label, randomised, pharmacokinetic (PK) and pharmacodynamic (PD) dose-ranging Phase II study of ticagrelor followed by a double-blind, randomised, parallel-group, placebo-controlled 4 weeksextension phase in paediatric patients with sickle cell diseaseOpenInterventionalNo
 Improving haematopoietic stem cell transplantation outcome - Improving haematopoeitic stem cell outcome through studies of alloreactivity, immune reconstitution, biomarkers and novel therapies.OpenObservationalYes, within lead country only
 Intelligent Stem Cell Culture Systems - Intelligent Stem Cell Culture SystemsOpenObservationalNo
76424792IVANOF1 Study - The Effect of Intravenous Iron on Postoperative Transfusion Requirements in Hip Fracture Patients – A Pilot StudyOpenInterventionalYes, within lead country only
 Long term outcome of Fanhdi® in Haemophilia A patients in London - Long term outcome of Fanhdi® in Haemophilia A patients in LondonOpenObservationalNo
 MCRN180 (AHEAD) - ADVATE HAEMOPHILIA OUTCOME DATABASE (AHEAD)OpenObservationalNo
 MCRN2640 (BAY59-7939_14374) - 30-day, single-arm study of the safety, efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in young children with various manifestations of venous thrombosisOpenInterventionalNo
 MCRN2759 (BAY59-7939_14372) - Multicentre, open-label, active-controlled, randomized study to evaluate the efficacy and safety of an age and body weight-adjusted rivaroxaban regimen in children with acute venous thromboembolismOpenInterventionalNo
 MCRN2926 (NN7999-3895) - An open-label single-arm multicentre non-controlled phase 3a trial investigating safety and efficacy of nonacog beta pegol (N9-GP) in prophylaxis and treatment of bleeding episodes in previously untreated patients with haemophilia B (FIX activity =2%)OpenInterventionalNo
 Measuring SCD patient satisfaction with hospital care for pain - A mixed methods study to adapt and pilot a brief questionnaire measure of sickle cell disease patients' satisfaction with hospital care during acute painful episodesOpenObservationalNo
 Molecular Investigation of Haematopoietic Malignancy - The investigation of molecular biological alterations in haematological malignancyOpenObservationalYes, within lead country only
 MSC in ITP - The Role of Bone Marrow Mesenchymal Stromal Cells in Chronic ITPOpenObservationalYes, within lead country only
 N-Acetylcysteine in patients with Sickle Cell Disease - N-Acetylcysteine in patients with Sickle Cell Disease. Reducing the incidence of daily life pain in patients with sickle cell diseaseOpenInterventionalNo
 Native T1 Mapping in Rare Diseases - Native T1 Mapping by Cardiovascular Resonance Imaging in Rare Diseases A New Method to Improve Patient CareOpenObservationalYes, within lead country only
 NIHR BioResource - Rare Diseases - National Institute for Health Research BioResource - Rare DiseasesOpenObservationalYes, within and outside lead country
 Oral anticoagulant agent associated bleeding events reporting system - Oral anticoagulant agent-associated bleeding events reporting system (ORANGE study).OpenObservationalYes, within and outside lead country
 Peripheral blood leukocytes in health and disease - Characterisation of peripheral blood leukocytes in health and diseaseOpenObservationalNo
 PoSCIS - The use of proteomics to develop novel plasma biomarkers to identify silent cerebral infarcts in children with sickle cell anaemiaOpenObservationalNo
46012373Prevention of morbidity in sickle cell disease: phase II (POMS 2b) - Prevention of morbidity in sickle cell disease Phase II (Improvement of Pain and Quality of Life in Patient with Sickle Cell Disease with Autoadjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b)OpenInterventionalYes, within lead country only
67322816PREVENTT - A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgeryOpenInterventionalNo
 RACE - A prospective Randomized multicenter study comparing horse Antithymocyte globuline (hATG) + Cyclosporine A (CsA) with or without Eltrombopag as front-line therapy for severe aplastic anemia patients.OpenInterventionalNo
26088319Red cell transfusion and QoL in myelodysplastic syndromes (REDDS) - Red blood cell transfusion thresholds and Quality of Life in myelodysplastic syndromes: a pilot, feasibility study.OpenInterventionalNo
79841657Reversal of over-anticoagulation with vitamin K - Reversal of over-anticoagulation using a ‘tailored’ vitamin K dosing regimen: towards a better management of anticoagulation therapyOpenInterventionalNo
86712308select-d - select-d: Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous ThromboembolismOpenInterventionalYes, within and outside lead country
 Sickle Cell Analgesia Protocol Evaluation (SCAPE) - Phase II evaluation of sub lingual fentanyl combined with oral oxycodone for acute pain management in adolescents and adults with acute painful crisis of sickle cell diseaseOpenInterventionalNo
 Structural brain abnormalities and hypoxia in sickle cell anaemia - Structural brain abnormalities and hypoxia in sickle cell anaemiaOpenInterventionalNo
 Study of haematology in newborns with Down syndrome and follow-up - Study of haematology in newborns with Down syndrome and follow-up. (Oxford-Imperial Down syndrome haematology cohort study)OpenObservationalNo
 TABI. - TABI: Thrombin Generation Assay to predict the efficacy of Bypassing agents in Haemophilia Patients with Inhibitors.OpenObservationalNo
 The development of an immunoglobulin (Ig) burden of treatment question - The development of an immunoglobulin (Ig) burden of treatment questionnaireOpenObservationalNo
 The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia - The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia and related syndromesOpenObservationalNo
 The Genetic Control and Predictive Value of HbF in Sickle Cell Disease - A Multi-centre, Genotype-phenotype Study to Investigate the Genetic Control and Predictive Value of Foetal Haemoglobin and F-cell Levels in Sickle Cell DiseaseOpenObservationalYes, within lead country only
 The Molecular Investigation of Unexplained Anaemias - The Molecular Investigation of Unexplained Anaemias and Related Congenital AnaemiasOpenObservationalYes, within and outside lead country
 The PEP-WARF Study - Developing Dosing Algorithms In Patients With Extreme Phenotypes Who Require Anticogaulation With Warfarin.OpenObservationalYes, within lead country only
84335288The TEMPLATE Study - A Randomised Controlled Trial Investigating the Pharmacodynamic Effect of Ticagrelor Monotherapy on Platelet Reactivity in Patients with Coronary Artery Disease: The TEMPLATE StudyOpenInterventionalNo
 Transitions from paediatric to adult services for sickle cell disease - Transitions from paediatric to adult services for sickle cell disease (SCD): a prospective qualitative study examining young adult patients’ experiencesOpenObservationalNo
73545489TREATT: Trial to EvaluAte Tranexamic acid therapy in Thrombocytopenia - A double blind, randomised controlled trial evaluating the safety and efficacy of Tranexamic acid in patients with haematological malignancies with severe thrombocytopeniaOpenInterventionalYes, within and outside lead country
 UK Childhood ITP Registry - The UK Paediatric ITP RegistryOpenObservationalYes, within lead country only
 UK TTP Registry - United Kingdom Thrombotic Thrombocytopenic Purpura Registry: A prospective study of Thrombotic Thrombocytopenic Purpura in the UKOpenObservationalYes, within and outside lead country
 UKAITPR - United Kingdom Adult Idiopathic Thrombocytopenic Purpura (ITP) Registry: An Investigation of Disease Progression, Treatment Effectiveness, and Co-morbid ConditionsOpenObservationalYes, within and outside lead country
 UK-PK Study - National Study of the Implementation of a Pharmacokinetic Focused Educational Package for patients living with Severe Haemophilia A.OpenObservationalNo




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