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UKCRN Study Portfolio > Haematology

Recruiting studies

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 ACIT - Activation of Coagulation and Inflammation in Trauma IIOpenObservationalYes, within and outside lead country
 Adherence to Prophylaxis among Young Haemophilia Patients - Adherence to Prophylactic Treatment among Adolescents and Young Adults with HaemophiliaOpenObservationalYes, within lead country only
 Adherence to Prophylaxis among Young People with Haemophilia - Adherence to prophylaxis among adolescents and young adults with haemophilia - questionnaire studyOpenObservationalYes, within lead country only
 Asthma and Nocturnal Hypoxia in Sickle Cell Anemia (SAC) II - Asthma and Nocturnal Hypoxia in Sickle Cell Anemia (SAC) IIOpenObservationalNo
 BRIDGE-BPD - Genetic analysis of inherited platelet conditionsOpenObservationalYes, within lead country only
 CCRN 1070 (Stroke AF) - GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial Fibrillation (Phase II/III – EU/EEA Member States)OpenObservationalNo
 CCRN 2300 (Haemophilia A) - Prospective, open-label, multicentre phase 3b study to assess the efficacy and safety of individually tailored prophylaxis with Human-cl rhFVIII in previously treated adult patients with severe haemophilia AOpenInterventionalNo
 CCRN 2498 (Venous Throboembolism) - PREFER in VTE Preventon of Thromboembolic Events - European Registry in Venous ThromboembolismOpenObservationalNo
 CCRN 680 (Hemophilia A) - Phase II/III partial randomized, open label trial using BAY 94-9027 for the prophylaxis and treatment of bleeding in severe Hemophilia A.OpenInterventionalNo
 CCRN 767 (Hemophilia A) - An Open-Label, Multicenter Evaluation of the Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor VIII Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia AOpenInterventionalNo
 CCRN 842 (Venous Thromboembolism) - Xalia- Xarelto for Long-term and Intitial Anticoagulation in Venous Thromboembolism (VTE)OpenInterventionalNo
 Developing enhanced audit & feedback interventions for transfusion_v1 - The development and evaluation of enhanced audit and feedback interventions to increase the uptake of evidence-based transfusion practice (AFFINITIE Programme, Workstream 1B)OpenObservationalNo
 DVT natural history, recurrence and PTS - The response of lower limb deep vein thrombosis to anticoagulation therapy: resolution, recurrence and post thrombotic syndrome.OpenObservationalNo
73819751ExACT Extended anticoagulation treatment for VTE: a randomised trial - A randomised controlled trial of extended warfarin treatment versus routine warfarin treatment for the prevention of recurrent venous thromboembolism and post thrombotic syndrome in patients being treated for a first episode of unprovoked VTEOpenInterventionalNo
 FIX Study - Evaluation of Assay Methodology to Optimise Clinical Management of Factor IX Replacement Therapy in Haemophilia BOpenObservationalNo
77951167Genotyping and platelet phenotyping (GAPP) - Mild bleeding disorders caused by platelet defectsOpenObservationalYes, within lead country only
 GRAPHICS - Genetic Regulators and Platelets in Cardiac SurgeryOpenObservationalNo
23537803HA-1 Heterologous Prime Boost Vaccine Study - A phase I clinical trial of the vaccination of healthy human volunteers against the minor histocompatibility antigen (mHAg) HA-1 using a DNA and MVA 'prime/boost' regimenOpenInterventionalNo
 Haemophilia: Investigating Physical Performance Outcomes (HIPPO) - An observational study in people with Haemophilia Investigating Physical Performance Outcomes (HIPPO)OpenObservationalYes, within lead country only
23996532HLA Epitope-Matched Platelet Transfusion Study - A comparison of HLA epitope-matched with standard HLA-matched platelet transfusions in raising the platelet count increment in alloimmunised thrombocytopenic patients with aplastic anaemia or low risk myelodysplastic syndrome: A double-blind randomised crossover superiority trial.OpenInterventionalYes, within lead country only
05026912InCiTE - Intracranial haemorrhage in thrombocytopenic haematology patients - Intracranial Haemorrhage in Thrombocytopenic Haematology Patients. A case control StudyOpenObservationalYes, within and outside lead country
 Intelligent Stem Cell Culture Systems - Intelligent Stem Cell Culture SystemsOpenObservationalNo
76424792IVANOF1 Study - The Effect of Intravenous Iron on Postoperative Transfusion Requirements in Hip Fracture Patients – A Pilot StudyOpenInterventionalYes, within lead country only
 MCRN224 (BAY 94-9027) - A multi-center, Phase III, uncontrolled, open-label trial to evaluate the pharmacokinetics, safety, and efficacy of BAY 94-9027 for prophylaxis and on-demand treatment in children (age <12 years) with severe hemophilia AOpenInterventionalNo
 Molecular Investigation of Haematopoietic Malignancy - The investigation of molecular biological alterations in haematological malignancyOpenObservationalYes, within lead country only
 MSC in ITP - The Role of Bone Marrow Mesenchymal Stromal Cells in Chronic ITPOpenObservationalNo
 Oral anticoagulant agent associated bleeding events reporting system - Oral anticoagulant agent-associated bleeding events reporting system (ORANGE study).OpenObservationalYes, within and outside lead country
 Peripheral blood leukocytes in health and disease - Characterisation of peripheral blood leukocytes in health and diseaseOpenObservationalNo
67322816PREVENTT - A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgeryOpenInterventionalYes, within lead country only
79841657Reversal of over-anticoagulation with vitamin K - Reversal of over-anticoagulation using a ‘tailored’ vitamin K dosing regimen: towards a better management of anticoagulation therapyOpenInterventionalNo
68222801Rivaroxaban in Antiphospholipid Syndrome (RAPS) - A prospective randomised controlled phase II/III clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLEOpenInterventionalNo
 Rivaroxaban Observational Safety Evaluation (ROSE) Study - An Observational Post-authorisation Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®) for the Prevention of Stroke in Patients with AF, Treatment of DVT and PE, and the Prevention of Recurrent DVT and PE in the Secondary Care Hospital Setting in England and WalesOpenObservationalYes, within lead country only
 SO-FIT - SO-FIT Study Of physical Function In adolescenTs with haemophiliaOpenObservationalYes, within lead country only
 Standard Care vs Pharmacokinetic Factor VIII Prophylaxis - Efficacy and cost effectiveness of standard versus pharmacokinetic dosing during factor VIII prophylaxis in adult patients with severe Haemophilia AOpenInterventionalNo
 Study of haematology in newborns with Down syndrome - Study of haematology in newborns with Down syndrome and follow-up. (Oxford-Imperial Down syndrome haematology cohort study)OpenObservationalYes, within and outside lead country
 The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia - The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia -OpenObservationalNo
 The Genetic Control and Predictive Value of HbF in Sickle Cell Disease - A Multi-centre, Genotype-phenotype Study to Investigate the Genetic Control and Predictive Value of Foetal Haemoglobin and F-cell Levels in Sickle Cell DiseaseOpenObservationalYes, within lead country only
 UK TTP Registry - United Kingdom Thrombotic Thrombocytopenic Purpura Registry: A prospective study of Thrombotic Thrombocytopenic Purpura in the UKOpenObservationalYes, within and outside lead country
 UKAITPR - United Kingdom Adult Idiopathic Thrombocytopenic Purpura (ITP) Registry: An Investigation of Disease Progression, Treatment Effectiveness, and Co-morbid ConditionsOpenObservationalYes, within and outside lead country
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