UK Clinical Research Network : Portfolio Database User Guide  
Welcome to the UK Clinical Research Network Study Portfolio : NIHR (England)  
UKCRN Study Portfolio > Haematology


Recruiting studies


< Amend search criteria

Export to Excel
ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 ACIT - Activation of Coagulation and Inflammation in Trauma IIOpenObservationalYes, within and outside lead country
 Adherence to Prophylaxis among Young Haemophilia Patients - Adherence to Prophylactic Treatment among Adolescents and Young Adults with HaemophiliaOpenObservationalYes, within lead country only
 Adherence to Prophylaxis among Young People with Haemophilia - Adherence to prophylaxis among adolescents and young adults with haemophilia - questionnaire studyOpenObservationalYes, within lead country only
 BRIDGE-BPD - Genetic analysis of inherited platelet conditionsOpenObservationalYes, within lead country only
 CCRN 1070 (Stroke AF) - GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial Fibrillation (Phase II/III – EU/EEA Member States)OpenObservationalNo
 CCRN 2492 (Sickle cell and anaemia) - The efficacy and safety of Ferriprox® for the treatment of transfusional iron overload in patients with sickle cell disease or other anaemiasOpenInterventionalNo
 CCRN 2622 (Haemophilia patients undergoing surgery) - A Phase 3, Multi-Center, Open Label Study of Efficacy and Safety of PEGylated rFVIII (BAX 855) in Previously Treated Patients With Severe Hemophilia A Undergoing Surgical or Other Invasive ProceduresOpenInterventionalNo
 CCRN 2979 (Haemophilia A) - A Phase 3b Continuation study of the Safety and Efficacy of PEGylated Recombinant Factor VIII (PEG-rFVIII; BAX 855) in Prophylaxis of Bleeding in Previously Treated Patients with Severe Hemophilia AOpenInterventionalNo
 CCRN 3132 (Beta-Thalassemia) - A PHASE 2A, OPEN-LABEL, DOSE FINDING STUDY TO DETERMINE THE SAFETY AND TOLERABILITY OF SOTATERCEPT (ACE-011) IN ADULTS WITH BETA-THALASSEMIAOpenInterventionalNo
 CCRN 698 (Haemophilia) - AN ASCENDING SINGLE DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS / PHARMACODYNAMICS OF PF-05280602, A RECOMBINANT FACTOR VIIA VARIANT (813D), IN ADULT HEMOPHILIA A AND B PATIENTS WITH OR WITHOUT INHIBITORSOpenInterventionalNo
 CCRN 757 (Haemophilia A) - EFFICACY AND SAFETY OF N8-GP DURING SURGICAL PROCEDURES IN PATIENTS WITH HAEMOPHILIA AOpenInterventionalNo
 CCRN 767 (Hemophilia A) - An Open-Label, Multicenter Evaluation of the Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor VIII Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia AOpenInterventionalNo
 DVT natural history, recurrence and PTS - The response of lower limb deep vein thrombosis to anticoagulation therapy: resolution, recurrence and post thrombotic syndrome.OpenObservationalNo
73819751ExACT Extended anticoagulation treatment for VTE: a randomised trial - A randomised controlled trial of extended warfarin treatment versus routine warfarin treatment for the prevention of recurrent venous thromboembolism and post thrombotic syndrome in patients being treated for a first episode of unprovoked VTEOpenInterventionalNo
 Feasibility of enhanced audit & feedback interventions (transfusion) v1 - The development and evaluation of enhanced audit and feedback interventions to increase the uptake of evidence-based transfusion practice (AFFINITIE Programme, Workstream 1C)OpenObservationalNo
 FIX Study - Evaluation of Assay Methodology to Optimise Clinical Management of Factor IX Replacement Therapy in Haemophilia BOpenObservationalNo
77951167Genotyping and platelet phenotyping (GAPP) - Mild bleeding disorders caused by platelet defectsOpenObservationalYes, within lead country only
 GRAPHICS - Genetic Regulators and Platelets in Cardiac SurgeryOpenObservationalNo
23537803HA-1 Heterologous Prime Boost Vaccine Study - A phase I clinical trial of the vaccination of healthy human volunteers against the minor histocompatibility antigen (mHAg) HA-1 using a DNA and MVA 'prime/boost' regimenOpenInterventionalNo
23996532HLA Epitope-Matched Platelet Transfusion Study - A comparison of HLA epitope-matched with standard HLA-matched platelet transfusions in raising the platelet count increment in alloimmunised thrombocytopenic patients with aplastic anaemia, myelodysplastic syndrome or acute myeloid leukaemia: A double-blind randomised crossover superiority trial.OpenInterventionalYes, within lead country only
05026912InCiTE - Intracranial haemorrhage in thrombocytopenic haematology patients - Intracranial Haemorrhage in Thrombocytopenic Haematology Patients. A case control StudyOpenObservationalYes, within and outside lead country
 Intelligent Stem Cell Culture Systems - Intelligent Stem Cell Culture SystemsOpenObservationalNo
76424792IVANOF1 Study - The Effect of Intravenous Iron on Postoperative Transfusion Requirements in Hip Fracture Patients – A Pilot StudyOpenInterventionalYes, within lead country only
 Long term outcome of Fanhdi® in Haemophilia A patients in London - Long term outcome of Fanhdi® in Haemophilia A patients in LondonOpenObservationalNo
 MCRN180 (AHEAD) - ADVATE HAEMOPHILIA OUTCOME DATABASE (AHEAD)OpenObservationalNo
 MCRN217 (12/LO/1166) - ADVATE 2ml (reconstituted in 2ml SWFI) European Union Post Authorisation Safety Surveillance StudyOpenObservationalNo
 MCRN227 (H7T-MC-TADO) - A Phase 3, Double-Blind, Randomized, Efficacy and Safety Comparison of Prasugrel and Placebo in Pediatric Patients with Sickle Cell DiseaseOpenInterventionalNo
 MCRN3225 (998HB303) - An Open-Label, Multicenter Evaluation of the Safety and Efficacy of Recombinant Coagulation Factor IX Fc Fusion Protein (rFIXFc; BIIB029) in the Prevention and Treatment of Bleeding in Previously Untreated Patients With Severe Hemophilia BOpenInterventionalNo
 Molecular Investigation of Haematopoietic Malignancy - The investigation of molecular biological alterations in haematological malignancyOpenObservationalYes, within lead country only
 MSC in ITP - The Role of Bone Marrow Mesenchymal Stromal Cells in Chronic ITPOpenObservationalYes, within lead country only
 Mutations associated with stroke in children with Sickle cell disease - Application of whole exome sequencing to identify mutations associated with stroke in paediatric patients less than 3 yrs of age with sickle cell anaemia.OpenObservationalNo
 Oral anticoagulant agent associated bleeding events reporting system - Oral anticoagulant agent-associated bleeding events reporting system (ORANGE study).OpenObservationalYes, within and outside lead country
 Parental confidence when dosing children. - Parental confidence when dosing children with long acting factor products in relation to sporting activity. A pilot study.OpenObservationalNo
 Peripheral blood leukocytes in health and disease - Characterisation of peripheral blood leukocytes in health and diseaseOpenObservationalNo
 PoSCIS - The use of proteomics to develop novel plasma biomarkers to identify silent cerebral infarcts in children with sickle cell anaemiaOpenObservationalNo
67322816PREVENTT - A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgeryOpenInterventionalYes, within lead country only
79841657Reversal of over-anticoagulation with vitamin K - Reversal of over-anticoagulation using a ‘tailored’ vitamin K dosing regimen: towards a better management of anticoagulation therapyOpenInterventionalNo
68222801Rivaroxaban in Antiphospholipid Syndrome (RAPS) - A prospective randomised controlled phase II/III clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLEOpenInterventionalNo
 Rivaroxaban Observational Safety Evaluation (ROSE) Study - An Observational Post-authorisation Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®) for the Prevention of Stroke in Patients with AF, Treatment of DVT and PE, and the Prevention of Recurrent DVT and PE in the Secondary Care Hospital Setting in England and WalesOpenObservationalYes, within lead country only
 SO-FIT - SO-FIT Study Of physical Function In adolescenTs with haemophiliaOpenObservationalYes, within lead country only
 Standard Care vs Pharmacokinetic Factor VIII Prophylaxis - Efficacy and cost effectiveness of standard versus pharmacokinetic dosing during factor VIII prophylaxis in adult patients with severe Haemophilia AOpenInterventionalNo
 Study of haematology in newborns with Down syndrome - Study of haematology in newborns with Down syndrome and follow-up. (Oxford-Imperial Down syndrome haematology cohort study)OpenObservationalYes, within and outside lead country
 THALAMOSS - THALAssaemia MOdular Stratification System for personalized therapy of betathalassaemia.OpenObservationalNo
 The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia - The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia and related syndromesOpenObservationalNo
 The Genetic Control and Predictive Value of HbF in Sickle Cell Disease - A Multi-centre, Genotype-phenotype Study to Investigate the Genetic Control and Predictive Value of Foetal Haemoglobin and F-cell Levels in Sickle Cell DiseaseOpenObservationalYes, within lead country only
 The Molecular Investigation of Unexplained Anaemias - The Molecular Investigation of Unexplained Anaemias and Related Congenital AnaemiasOpenObservationalYes, within and outside lead country
 UK TTP Registry - United Kingdom Thrombotic Thrombocytopenic Purpura Registry: A prospective study of Thrombotic Thrombocytopenic Purpura in the UKOpenObservationalYes, within and outside lead country
 UKAITPR - United Kingdom Adult Idiopathic Thrombocytopenic Purpura (ITP) Registry: An Investigation of Disease Progression, Treatment Effectiveness, and Co-morbid ConditionsOpenObservationalYes, within and outside lead country




england.ukcrn.org.uk/search
If you experience problems using the application, please click here.