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UKCRN Study Portfolio > Haematology


Recruiting studies


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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 ACIT - Activation of Coagulation and Inflammation in Trauma IIOpenObservationalYes, within and outside lead country
15490813Affinitie: Two cluster RCTs to evaluate feedback in blood transfusion audits - Affinitie: Two linked cluster randomised trials to evaluate feedback interventions embedded within a national audit of blood transfusion practiceOpenInterventional and ObservationalYes, within and outside lead country
 BRIDGE-BPD - Genetic analysis of inherited platelet conditionsOpenObservationalYes, within lead country only
 CCRN 1070 (Stroke AF) - GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In Patients with Atrial Fibrillation (Phase II/III – EU/EEA Member States)OpenObservationalNo
 CCRN 2078 - A PHASE 1 PROSPECTIVE, UNCONTROLLED, OPEN-LABEL, MULTICENTER, DOSEESCALATION STUDY EVALUATING THE SAFETY AND PHARMACOKINETICS IN HEREDITARY TTP (THROMBOTIC THROMBOCYTOPENIC PURPURA)OpenInterventionalNo
 CCRN 2236 (Reversal agent bleeding) - A Phase III, case series clinical study of the reversal of the anticoagulant effects of dabigatran by intravenous administration of 5.0 g idarucizumab (BI 655075) in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.OpenInterventionalNo
 CCRN 2492 (Sickle cell and anaemia) - The efficacy and safety of Ferriprox® for the treatment of transfusional iron overload in patients with sickle cell disease or other anaemiasOpenInterventionalNo
 CCRN 2577 (Thrombocytopenic Purpura) - A Cross-Sectional Study of Patients with Chronic Immune Thrombocytopenic Purpura and Caregivers to Estimate the Proportion who Administer Romiplostim Correctly After Receipt of Home Administration Training MaterialsOpenObservationalNo
 CCRN 2622 (Haemophilia patients undergoing surgery) - A Phase 3, Multi-Center, Open Label Study of Efficacy and Safety of PEGylated rFVIII (BAX 855) in Previously Treated Patients With Severe Hemophilia A Undergoing Surgical or Other Invasive ProceduresOpenInterventionalNo
 CCRN 2692 (Venous Thromboembolism) - MULTICENTER, RANDOMIZED, ACTIVE-CONTROLLED EFFICACY AND SAFETY STUDY COMPARING EXTENDED DURATION BETRIXABAN WITH STANDARD OF CARE ENOXAPARIN FOR THE PREVENTION OF VENOUS THROMBOEMBOLISM IN ACUTE MEDICALLY ILL PATIENTSOpenInterventionalNo
 CCRN 2939 (Haemophilia) - A Phase 1 Single-ascending and Multiple-ascending Dose, Safety, Tolerability and Pharmacokinetics Study of Subcutaneously Administered ALN-AT3SC in Healthy Adult Volunteers and Hemophilia A or B Patients (Moderate or Severe Hemophilia)OpenInterventionalNo
 CCRN 2979 (Haemophilia A) - A Phase 3b Continuation study of the Safety and Efficacy of PEGylated Recombinant Factor VIII (PEG-rFVIII; BAX 855) in Prophylaxis of Bleeding in Previously Treated Patients with Severe Hemophilia AOpenInterventionalNo
 CCRN 3064 (Chronic Immune Thrombocytopenic Purpura) - A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Persistent/Chronic Immune Thrombocytopenic PurpuraOpenInterventionalNo
 CCRN 3248 (Thromboembolism) - Reduced-dosed rivaroxaban and standard-dosed rivaroxaban versus ASA in the longtermprevention of recurrent symptomatic venous thromboembolism in patients withsymptomatic deep-vein thrombosis and/or pulmonary embolismThe Einstein Choice StudyOpenInterventionalNo
 CCRN 757 (Haemophilia A) - EFFICACY AND SAFETY OF N8-GP DURING SURGICAL PROCEDURES IN PATIENTS WITH HAEMOPHILIA AOpenInterventionalNo
 CCRN 767 (Hemophilia A) - An Open-Label, Multicenter Evaluation of the Long-Term Safety and Efficacy of Recombinant Human Coagulation Factor VIII Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding Episodes in Previously Treated Subjects With Hemophilia AOpenInterventionalNo
 Cohort study investigating haemophilic arthropathy development V0.01 - Evaluation of the Effect of Musculoskeletal and Exercise Factors on the Development of Joint Disease in Haemophilia.OpenObservationalYes, within lead country only
 DVT natural history, recurrence and PTS - The response of lower limb deep vein thrombosis to anticoagulation therapy: resolution, recurrence and post thrombotic syndrome.OpenObservationalNo
 Feasibility of enhanced audit & feedback interventions (transfusion) v1 - The development and evaluation of enhanced audit and feedback interventions to increase the uptake of evidence-based transfusion practice (AFFINITIE Programme, Workstream 1C)OpenObservationalNo
 Follow-up in Rivaroxaban patients in setting of thromboembolism - FIRST Registry: Follow-up in Rivaroxaban Patients in the Setting of ThromboembolismOpenObservationalYes, within lead country only
 GARFIELD-VTE - Global Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real worldOpenObservationalNo
77951167Genotyping and platelet phenotyping (GAPP) - Mild bleeding disorders caused by platelet defectsOpenObservationalYes, within lead country only
23537803HA-1 Heterologous Prime Boost Vaccine Study - A phase I clinical trial of the vaccination of healthy human volunteers against the minor histocompatibility antigen (mHAg) HA-1 using a DNA and MVA 'prime/boost' regimenOpenInterventionalNo
 HAEM 3368 (Film-coated tablet) - A randomized, open-label, multicenter, two arm, phase II study to investigate the benefits of an improved deferasirox formulation (film-coated tablet)OpenInterventionalNo
 HAEM 3662 - A PHASE 1B, RANDOMISED, DOUBLE-BLIND (SPONSOR OPEN), PLACEBO CONTROLLED STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF 04447943, CO-ADMINISTERRED WITH AND WITHOUT HYDROXYUREA IN SBJECTS WITH STABLE SICKLE CELL DISEASEOpenInterventionalNo
 HAEM 3802 - Open Label, Adaptive Design, Ascending, Multiple-Dose Study to Evaluate Safety and Efficacy of BMS-986004 (Anti-CD40L dAb) in Adult Subjects with Primary Immune Thrombocytopenia (ITP)OpenInterventionalNo
 HAEM3543 (261202) - A PHASE 3 PROSPECTIVE, UNCONTROLLED, MULTICENTER STUDY EVALUATING PHARMACOKINETICS, EFFICACY, SAFETY, AND IMMUNOGENICITY OF BAX 855(PEGYLATEDFULLLENGTH RECOMBINANT FVIII) IN PREVIOUSLY TREATED PEDIATRIC PATIENTS WITH SEVERE HEMOPHILIA AOpenInterventionalNo
 HAEM3579 (20101221) - A Single Arm, Open-label, Long-term Efficacy and Safety Study of Romiplostim in Thrombocytopenic Pediatric Subjects With Immune Thrombocytopenia (ITP)OpenInterventionalNo
 HAEM3709 (D5136C00007) - Multicenter, open-label, randomised, pharmacokinetic (PK) and pharmacodynamic (PD) dose-ranging Phase II study of ticagrelor followed by a double-blind, randomised, parallel-group, placebo-controlled 4 weeksextension phase in paediatric patients with sickle cell diseaseOpenInterventionalNo
23996532HLA Epitope-Matched Platelet Transfusion Study - A comparison of HLA epitope-matched with standard HLA-matched platelet transfusions in raising the platelet count increment in alloimmunised thrombocytopenic patients with aplastic anaemia, myelodysplastic syndrome or acute myeloid leukaemia: A double-blind randomised crossover superiority trial.OpenInterventionalYes, within lead country only
05026912InCiTe - Intracranial haemorrhage in thrombocytopenic haematology patients - Intracranial Haemorrhage in Thrombocytopenic Haematology Patients. A case control StudyOpenObservationalYes, within and outside lead country
 Intelligent Stem Cell Culture Systems - Intelligent Stem Cell Culture SystemsOpenObservationalNo
76424792IVANOF1 Study - The Effect of Intravenous Iron on Postoperative Transfusion Requirements in Hip Fracture Patients – A Pilot StudyOpenInterventionalYes, within lead country only
 Long term outcome of Fanhdi® in Haemophilia A patients in London - Long term outcome of Fanhdi® in Haemophilia A patients in LondonOpenObservationalNo
 MCRN180 (AHEAD) - ADVATE HAEMOPHILIA OUTCOME DATABASE (AHEAD)OpenObservationalNo
 MCRN217 (12/LO/1166) - ADVATE 2ml (reconstituted in 2ml SWFI) European Union Post Authorisation Safety Surveillance StudyOpenObservationalNo
 MCRN2640 (BAY59-7939_14374) - 4-week, open-label, multiple-dose study of the safety and the pharmacokinetic and pharmacodynamic properties of the oral direct factor Xa inhibitor rivaroxaban in pediatric subjects aged = 6 months to <6 years with venous thromboembolismOpenInterventionalNo
 MCRN2759 (BAY59-7939_14372) - Multicentre, open-label, active-controlled, randomized study to evaluate the efficacy and safety of an age and body weight-adjusted rivaroxaban regimen in children with acute venous thromboembolismOpenInterventionalNo
 MCRN3225 (998HB303) - An Open-Label, Multicenter Evaluation of the Safety and Efficacy of Recombinant Coagulation Factor IX Fc Fusion Protein (rFIXFc; BIIB029) in the Prevention and Treatment of Bleeding in Previously Untreated Patients With Severe Hemophilia BOpenInterventionalNo
 Molecular Investigation of Haematopoietic Malignancy - The investigation of molecular biological alterations in haematological malignancyOpenObservationalYes, within lead country only
 MSC in ITP - The Role of Bone Marrow Mesenchymal Stromal Cells in Chronic ITPOpenObservationalYes, within lead country only
 Oral anticoagulant agent associated bleeding events reporting system - Oral anticoagulant agent-associated bleeding events reporting system (ORANGE study).OpenObservationalYes, within and outside lead country
 Parental confidence when dosing children. - Parental confidence when dosing children with long acting factor products in relation to sporting activity. A pilot study.OpenObservationalNo
 Peripheral blood leukocytes in health and disease - Characterisation of peripheral blood leukocytes in health and diseaseOpenObservationalNo
 PoSCIS - The use of proteomics to develop novel plasma biomarkers to identify silent cerebral infarcts in children with sickle cell anaemiaOpenObservationalNo
 Prevention of Morbidity in Sickle Cell Disease - 2a: Pilot phase - Prevention of Morbidity in Sickle Cell Disease 2a - pilot phase. (POMS 2a) Improvement of Pain and Quality of Life in Patients with Sickle Cell Disease with Nocturnal Oxygen Therapy or Auto-adjusting Continuous Positive Pressure: pilot phaseOpenInterventionalNo
67322816PREVENTT - A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgeryOpenInterventionalNo
26088319Red cell transfusion and QoL in myelodysplastic syndromes (REDDS) - Red blood cell transfusion thresholds and Quality of Life in myelodysplastic syndromes: a pilot, feasibility study.OpenInterventionalNo
79841657Reversal of over-anticoagulation with vitamin K - Reversal of over-anticoagulation using a ‘tailored’ vitamin K dosing regimen: towards a better management of anticoagulation therapyOpenInterventionalNo
 Rivaroxaban Observational Safety Evaluation (ROSE) Study - An Observational Post-authorisation Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®) for the Prevention of Stroke in Patients with AF, Treatment of DVT and PE, and the Prevention of Recurrent DVT and PE in the Secondary Care Hospital Setting in England and WalesOpenObservationalYes, within lead country only
86712308select-d - select-d: Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous ThromboembolismOpenInterventionalYes, within and outside lead country
 Study of haematology in newborns with Down syndrome and follow-up - Study of haematology in newborns with Down syndrome and follow-up. (Oxford-Imperial Down syndrome haematology cohort study)OpenObservationalNo
 THALAMOSS - THALAssaemia MOdular Stratification System for personalized therapy of betathalassaemia.OpenObservationalNo
 The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia - The Genetic Basis of Dsykeratosis Congenita and Aplastic Anaemia and related syndromesOpenObservationalNo
 The Genetic Control and Predictive Value of HbF in Sickle Cell Disease - A Multi-centre, Genotype-phenotype Study to Investigate the Genetic Control and Predictive Value of Foetal Haemoglobin and F-cell Levels in Sickle Cell DiseaseOpenObservationalYes, within lead country only
 The Molecular Investigation of Unexplained Anaemias - The Molecular Investigation of Unexplained Anaemias and Related Congenital AnaemiasOpenObservationalYes, within and outside lead country
 UK Childhood ITP Registry - The UK Paediatric ITP RegistryOpenObservationalYes, within lead country only
 UK TTP Registry - United Kingdom Thrombotic Thrombocytopenic Purpura Registry: A prospective study of Thrombotic Thrombocytopenic Purpura in the UKOpenObservationalYes, within and outside lead country
 UKAITPR - United Kingdom Adult Idiopathic Thrombocytopenic Purpura (ITP) Registry: An Investigation of Disease Progression, Treatment Effectiveness, and Co-morbid ConditionsOpenObservationalYes, within and outside lead country




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