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| | 18F-FMISO PET following traumatic brain injury - Defining the burden of cerebral ischaemia following head injury using 18F positron emission tomography | Closed | Observational | N/A |
| 00441706 | 3MG - A Randomised Trial of Nebulised versus IV Magnesium Sulphate versus Placebo for Acute Severe Asthma | Closed | Interventional | N/A |
| | A pilot randomised controlled trial of the introcular use of Triamcinolone - A pilot randomised controlled trial of the introcular use of Triamcinolone Acetonide to prevent proliferative vitreoretinopathy (PVR) in eyes undergoing vitreoretinal surgery for open globe trauma (OGT) | Open | Observational | -unknown- |
| | A study of how domestic violence is named & responded to in A&E depts - An examination of how domestic violence is constructed and responded to in emergency department contacts of women attending emergency departments in Lancashire | Closed | Observational | N/A |
| | Adenosine testing to DEtermine the need for Pacing Therapy (ADEPT-ILR) - Adenosine testing to DEtermine the need for Pacing Therapy with the additional use of an Implantable Loop Recorder (ADEPT-ILR study):
Efficacy of Permanent Pacing in Patients Presenting to Emergency Medical Services with Unexplained Syncope and a Positive Intravenous Adenosine Test: A Randomised, Double Blind,Placebo Controlled, Cross Over Trial | Open | Interventional | No |
| | AIM (Assisted Intention Monitoring) - A randomised controlled trial of the impact of electronically delivered 'content free' cueing on psychological functioning following brain injury. | Closed | Interventional | N/A |
| 04180738 | AIM: Ankle Injury Management - Comparison of close contact cast (CCC) technique to open surgical reduction and internal fixation (ORIF) in the treatment of unstable ankle fractures in patients over 60 years | Open | Interventional | No |
| 18528625 | Airway Management Feasibility Study (REVIVE-Airways) - Randomised comparison of the effectiveness of the Laryngeal Mask Airway Supreme, i-gel and current practice in the initial airway management of pre-hospital cardiac arrest: a feasibility study (REVIVE-Airways) | Closed | Interventional | N/A |
| | Ambulance Clinician QI Survey Final v1.0 - Engaging Ambulance Clinicians in Quality Improvement: Questionnaire Study | Closed | Observational | N/A |
| | Ambulance Service handover study - Improving the quality of ambulance crew handovers: A qualitative study of knowlege transfer in emergency care teams. | Closed | Observational | N/A |
| | Analysis of Burn Wound Environment for Development of Smart Dressings - Analysis of burn wound environment including burn wound exudate and plasma for development of smart dressings and biomarkers for targeted detection of wound infection using nano-technology. | Open | Observational | No |
| | Anticoagulation of Calf Thrombosis (ACT): A Pilot Feasibility Study - The Anticoagulation of Calf Thrombosis (ACT) Study: A randomised controlled trial comparing standardised anticoagulation versus conservative therapy in the treatment of below knee deep vein thrombosis | Closed | Interventional | N/A |
| 81174170 | AS04 Ankle study of fracture treatment in the older patient - Influence of ankle skin perfusion on fracture treatment outcomes in the elderly. A randomised controlled trial comparing total contact cast with open reduction and internal fixation the effect on cutaneous blood supply and relationship to skin complications | Closed | Interventional | N/A |
| 94772165 | Assessing effectiveness of an e-learning tool to aid junior doctor management of febrile children - Refining evaluation methodologies for interventions that change practice (REMIT): A model to assess the effectiveness of an e-learning tool in improving the management of febrile children by junior doctors | Closed | Interventional | N/A |
| | Benefit of Rehabilitation After Head Injury Measuring S100B - In patients presenting to the Emergency Department, can serum S100B concentrations following minor head injury predict those most likely to benefit from neuro-rehabilitation? | Closed | not specified | N/A |
| | Biomarkers in paediatric sepsis - A pilot evaluation of two novel biomarkers in the early diagnosis of paediatric sepsis | Closed | Observational | N/A |
| | BIOPAR - Biomarkers of paracetamol hepatotoxicity | Open | Interventional | Yes, within lead country only |
| | Can Paramedics use FRAX to Reduce Fracture Risk in Patients who Fall? - Can Ambulance Paramedics use FRAX (the WHO Fracture Risk Assessment Tool) to help GPs improve Future Fracture Risk in Patients that Fall? | In Set-Up Pending NHS Permission | Observational | No |
| | CCRN 400 (B-AHEAD) - An observational clinical study of the BrainScope Ahead M-100 hand held electroencephalogram in Emergency department patients with head injury (B-AHEAD UK Trial) | Closed | Interventional and Observational | N/A |
| | CCRN 515 (Acute pain) - A randomised, double blind, multi-centre, placebo controlled study to evaluate the efficacy and safety of methoxyflurane (Penthrox™) for the treatment of acute pain in patients presenting to an Emergency Department with minor trauma | Closed | Interventional | N/A |
| | CCRN 552 (Haemorrhagic Shock) - A multi-centre, randomised, double-blind, controlled study to
evaluate the safety and efficacy of MP4OX treatment, in addition to standard treatment, in severely injured trauma patients with lactic acidosis due to haemorrhagic shock | Closed | Interventional | N/A |
| | CCRN 981 (Burn Wounds) - Open, Blindly Evaluated, Prospective, Controlled, Randomized, Multicenter Phase III Clinical Trial to Compare Intraindividually the Efficacy and Tolerance of OleogelS10 versus Standard of Care in Accelerating the Healing of Grade 2a PartialThickness Burn Wounds | Open | Interventional | No |
| | CO Monitoring Study - Prevalence of Co exposure in patients attending emergency departments | Closed | Observational | N/A |
| | Cognitive behavioural therapy in fear of falling: Therapy development - Cognitive behavioural therapy-based intervention to reduce fear of falling in older patients attending a community falls service: Therapy development and randomised controlled trial. 1. Therapy development and ethnographic substudy | Closed | Observational | N/A |
| | Compassion in Emergency Care - Compassion in Emergency Care: Compassion Satisfaction, Burnout and Compassion Fatigue in Senior Emergency Physicians | Withdrawn During Setup | Observational | No |
| 86750102 | CRASH-2 - Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage | Closed | Interventional | N/A |
| | CRASH-3 - Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: An International, Randomised, Double Blind, Placebo Controlled Trial. | Open | Interventional | Yes, within lead country only |
| | CT Angiograms in Open Tibial Fractures - Investigating The Frequency and Effects of Concomitant Vascular Injury on Union in Open Tibial Fractures | Open | Observational | No |
| | Decision Making and Safety in Emergency Care Transitions_Service Users - Decision Making and Safety in Emergency Care Transitions_Service Users | Open | Observational | No |
| | DETECT mTBI - Dynamic Evolution of Temporal Changes in Mild to Moderate Traumatic Brain Injury | Open | Observational | No |
| 31379280 | Distal Radius Acute Fracture Fixation Trial - A Randomised Controlled Trial of Percutaneous Fixation with Kirschner Wires versus Volar Locking-Plate Fixation in the Treatment of Adult Patients with a Dorsally Displaced Fracture of the Distal Radius | Closed | Interventional | N/A |
| 55509212 | Early Cryoprecipitate for Severe Trauma Haemorrhage Trial (CRYOSTAT) - A feasibility study for a multi-centre, randomised controlled study evaluating the effects of early administration of cryoprecipitate in major traumatic haemorrhage | Open | Interventional | Yes, within lead country only |
| | EDiT - The impact of foundation doctor training: Impact on workforce well-being and patient care. | Closed | Observational | N/A |
| | EDiT phase 2 - The impact of foundation doctor training: impact on workforce well-being and patient care - phase 2 (The EDiT Study) | Closed | Observational | N/A |
| 38764966 | Effects of physostigmine and modafinil in patients post head injury - Effects of physostigmine and modafinil in patients post head injury | Closed | Interventional | N/A |
| | Emergency Care Handover (ECHO) v1 - Clinical Handovers within the Emergency Care Pathway and the Potential for Harm of Clinical Handover Failures | Closed | Observational | N/A |
| | ENCEPH UK - Cohort Studies - ENCEPH UK - Cohort Studies (Retrospective Cohort & Prospective Cohort) | Open | Observational | Yes, within lead country only |
| | Environmental interventions for falls prevention - Environmental interventions for falls prevention:Users’ experiences and opinions | Closed | Observational | N/A |
| | ETPOS - ETPOS: European Transfusion Practice and Outcome Survey. An observational outcome study of transfusion practice in surgical patients (excluding cardiothoracic surgery) throughout Europe. | In Set-Up NHS Permission Received | Observational | No |
| | Exploring Motivations to Self-Harm - Exploring Motivations to Self-Harm | Closed | Observational | N/A |
| 03605270 | FAST (First-aid Advice and Safety Training) Parent programme - The FAST (First-aid Advice and Safety Training) Parent programme for the prevention of recurrent home injuries in preschool children | Closed | Interventional | N/A |
| 16152419 | FIB trial - Randomised trial of the fascia-iliaca block versus the 'three-in-one' block for femoral neck fractures in the emergency department | Closed | Interventional | N/A |
| | Free Light Chains in Emergency Care - A study to investigate the role of combined serum free lights chains (cFLCS), the modified emergency warning score (MEWS) and the early warning score (EWS) in emergency care. | Open | Observational | No |
| | Haemorrhage Alleviation with Tranexamic Acid [HALT-IT] - Tranexamic Acid for the Treatment of Gastrointestinal Haemorrhage: An International Randomised, Double Blind Placebo Controlled Trial | Open | Interventional | Yes, within lead country only |
| | HetOss - MRI Appearances of Heterotopic Ossification in Subacute Spinal Cord Injuries | Open | Observational | Yes, within lead country only |
| | HITS-NS a Feasibility Study - Head Injury Transportation Straight to Neurosurgery (HITS-NS) - A Feasibility Study | Open | Interventional | No |
| | Identification of Biomarkers for Burn Pain - Metabolic Characterisation of Human Models of Burn Pain - Identification of Biomarkers for Burn Pain | Open | Observational | No |
| | Interview study with Sure Start Children Centre staff - Identifying Barriers and Facilitators to Injury Prevention - Finding Out What Is Known and Undertaking New Work. A Qualitative Study of Sure Start Children's Centre Managers and Staff | Closed | Observational | N/A |
| | Intravenous paracetamol compared to intravenous morphine for pain in the emergency department: a ran - Intravenous paracetamol compared to intravenous morphine for pain in the emergency department: a randomised controlled trial | Closed | Interventional | N/A |
| | Investigating Lower Limb Trauma - Investigating the Outcomes of Lower Limb Trauma Patients | Open | Observational | No |
| | IS-PROVE version 2 - Patient reported outcomes for vascular emergencies (PROVE): interview study of patients and practitioners for developing PROVE (IS-PROVE) | Closed | Observational | N/A |
| | IV-AID IV fluid and the Acutely Intoxicated - The estimation of blood alcohol concentrations in intoxicated individuals treated with intravenous fluid | Open | Interventional | No |
| 76424792 | IVANOF1 Study - The Effect of Intravenous Iron on Postoperative Transfusion Requirements in Hip Fracture Patients – A Pilot Study | Open | Interventional | No |
| | James Lind Alliance Pressure Ulcer Priority Setting Process - James Lind Alliance Pressure Ulcer Priority Setting Process | Closed | Observational | N/A |
| | Kiosk Injury Surveillance System (KISS) - Kiosk Injury Surveillance System (KISS): Is injury data self-entered by patients using computer kiosks as good as that obtained by hospital staff during a consultation? | Open | Observational | Yes, within lead country only |
| | Leicester Diagnostics Unit Initial Study - Multi-modality Monitoring in Emergency Care - Observational Study | Open | Observational | No |
| | Meningitis NorthWest - Meningitis North West: Epidemiology and outcomes in meningitis in the North of England A prospective,observational, cohort study | Open | Observational | Yes, within lead country only |
| | Models of Care for the Delivery of Secondary Fracture Prevention - Models of Care for the Delivery of Secondary Fracture Prevention after Hip Fracture: A Health Service Cost, Clinical Outcomes and Cost-effectiveness Study within the South Central Region | In Set-Up Pending NHS Permission | Observational | No |
| | National survey of Sure Start Children's Centres - National survey of Sure Start Children's Centres | Closed | Observational | N/A |
| 25343280 | PAin SoluTions In the Emergency Setting (PASTIES) - An open randomised trial of patient controlled analgesia (PCA) versus routine care in the Emergency Department | Open | Interventional | No |
| 08233942 | PARAMEDIC - PaRAMeDIC: Prehospital Randomised Assessment of a Mechanical compression Device In Cardiac arrest | Open | Interventional | No |
| | Paramedic Ultrasound Examination PULSE Study - Can paramedics use portable ultrasound to identify free abdominal fluid and abdominal aortic aneurysm following a short course? | Closed | Interventional | N/A |
| 03362357 | Parathyroid Hormone in the recovery from hip fractures - a pilot study - The administration of Parathyroid hormone affects functional recovery from pertrochanteric fractured neck of femur: A prospective randomised comparative pilot study with blinded objective functional outcome assessment | Open | Interventional | No |
| | Parent's experience of urgent care services - To understand and improve the experience of parents and carers who need advice when a child has a fever (high temperature) | Closed | Observational | N/A |
| | Phase 3 WaLLTR Development - Patient recovery and clinical results in major lower limb fractures new technologies and patient centred outcomes | Open | Observational | No |
| | PhOEBE - Developing New Ways of Measuring the Impact of Ambulance Service Care | Open | Observational | No |
| 71002650 | PreFIT - Prevention of Fall Injury Trial | Open | Interventional | Yes, within lead country only |
| | Preventable Incidents, Survival and Mortality Study (PRISM) - Preventable Incidents, Survival and Mortality Study (PRISM) | Closed | Observational | N/A |
| | Promoting well-being after injury - Promoting well-being after injury: The impact of post-traumatic stress on emergency department patients with head and orthopaedic injuries | Closed | Observational | N/A |
| 36307479 | Protocolised Management in Sepsis (ProMISe); v1.0 - Protocolised Management in Sepsis: A multicentre, randomised controlled trial of the clinical and cost-effectiveness of early goal-directed protocolised resuscitation for emerging septic shock | Open | Interventional | Yes, within and outside lead country |
| | Randomised Controlled Trial of a New Brace for Fractured Neck of Femur - Evaluation of the Nottingham ComfiBrace for Fracture Neck of Femur Patients for Ambulance and Hospital Patient Transfer | Open | Interventional | No |
| 44972300 | REFINE Study - The REFINE (REducing Falls in IN-patient Elderly) Study | Closed | Interventional | N/A |
| 65792154 | ReMemBrIn - Rehabilitation of Memory following Traumatic Brain Injury – A Phase III Randomised Controlled Trial | Open | Interventional | No |
| 67937027 | REVERT - Randomised Evaluation of Modified Valsalva Effectivness in Re-entrant Tachycardia (REVERT) Study | Open | Interventional | No |
| | REVIVE-Qualy - An Exploration of the Views of Paramedics Regarding Airway and Resuscitation Research | Open | Observational | No |
| | SAFETIME - What are the safety, quality and training implications of the four-hour targert for emergency departments in the UK? | Closed | Observational | N/A |
| | SCARTA: A Simple Cognitive Task after a Road Traffic Accident - A simple cognitive task to reduce the build-up of flashbacks after a road traffic accident: A randomised controlled study in an emergency department | Open | Interventional | No |
| | SCI-Incidence of lower limb fractures - Incidence of lower limb fractures in persons with chronic spinal cord injury | Closed | Observational | N/A |
| | Sensorimotor control of amputee gait - Recent developments in lower-limb prostheses: To gain full advantage of improved mechanical function are sensorimotor control features necessary? | Closed | Observational | N/A |
| | Sequelae of mild traumatic brain injury - An investigation into the predictability of psychological and social disability following mild or moderate traumatic brain injury | Closed | Observational | N/A |
| | SIFTI - Scientific Investigation of the Biological Pathways Following Thermal Injury in Adults and Children | Open | Observational | Yes, within lead country only |
| | SIPS junior - Developing and evaluating interventions for adolescent alcohol use disorders presenting through emergency departments – Prevalence study | Open | Observational | No |
| | SSEPs - Prognostic Value of Upper Limb SSEPs in Hypoxic Brain Injury with Therapeutic Induced Mild Hypothermia | Open | Interventional | No |
| 19321911 | STITCH (TRAUMA) - Surgical Trial In Traumatic intraCerebral Haemorrhage | Suspended | Interventional | Yes, within and outside lead country |
| | SWIFFT Trial - A multi-centre randomised controlled trial evaluating cast treatment versus surgical fixation on wrist function for fractures of the scaphoid waist in adults | In Set-Up Pending NHS Permission | Interventional | Yes, within lead country only |
| | Taking healthcare to the community ('Smartpods') - Taking healthcare to the community: the views of NHS Trust staff on change in the provision of urgent and emergency care ('Smartpods') | Closed | Observational | N/A |
| | The AHEAD study - The AHEAD study: Managing anticoagulated patients who suffer head injury | Closed | Observational | N/A |
| | The HIP-HOP Flooring Study: Helping Injury Prevention in Hospitalised Older People - Pilot cluster randomised controlled trial of flooring to reduce injuries from falls in elderly care units. | Closed | Interventional | N/A |
| | The impact of immediate reporting in the ED - The impact of radiographer immediate reporting on patient outcomes and service delivery within the emergency department: A randomised controlled trial | Closed | Interventional | N/A |
| | The Manchester Acute Coronary Syndromes (MACS) Trial - Reducing Unnecessary Admissions for Chest Pain with the Manchester Acute Coronary Syndromes (MACS) Decision Rule: Feasibility Study | In Set-Up Pending NHS Permission | Interventional | No |
| | The Paediatric Observation Priority Score (POPS) - An evaluation of the Paediatric Observation Priority Score in predicting appropriate admission and safe discharge from a Children's Emergency Department | Open | Observational | Yes, within lead country only |
| | The PAINTED Study - PAndemic INfluenza Triage in the Emergency Department | Open | Observational | Yes, within lead country only |
| | The Steroids and Immunity from Injury to Rehab Study (Civilian) - The Steroids and Immunity from Injury through to Rehabilitation Study (SIR). (Civilian Arm.) | Closed | Observational | N/A |
| | The transplantation of autologous olfactory ensheathing cells into brachial plexus - The transplantation of autologous olfactory ensheathing cells into brachial plexus injuries: study of safety and efficacy | Open | Observational | No |
| 93732214 | TICH2 - Tranexamic acid for IntraCerebral Haemorrhage TICH2 | Open | Interventional | No |
| 85757829 | Transfusion in Gastrointestinal Bleeding -TRIGGER - A multi-centre, feasibility, cluster randomised controlled trial comparing restrictive versus liberal blood transfusion strategies in adult patients admitted with acute upper gastrointestinal bleeding. | Closed | Interventional | N/A |
| | Trauma Coagulopathy and Massive Transfusion - Activation of Coagulation and Inflammation in Trauma II | Open | Observational | Yes, within lead country only |
| | Traumatic Coagulopathy and Massive Transfusion - Traumatic Coagulopathy and Massive Transfusion: Improving outcomes and Saving Blood | Closed | Observational | N/A |
| 99771224 | UK FixDT - UK Fixation of Distal Tibia Fractures - Locking-plate Fixation versus Intramedullary Nail Fixation for Patients with a Displaced, Extra-articular Fracture of the Distal Tibia: A Randomised Trial and Economic Evaluation | Open | Interventional | Yes, within lead country only |
| | Understanding wound healing and scar formation - Understanding wound healing and scar formation | In Set-Up NHS Permission Received | Observational | No |
| | Users' Views of the Quality of Emergency Ambulance Services - Pre Hospital Outcomes for Evidence Based Evaluation (PHOEBE): Users' Views of the Quality of Emergency Ambulance Services | Closed | Observational | N/A |
| | Warwick Hip Trauma Evaluation (WHiTE Study) - Warwick Hip Trauma Evaluation: A Comprehensive Cohort Study of Patients with Fracture of the Proximal Femur. The WHiTE Study | Open | Observational | No |
| 55006384 | Warwick Spinal Immobiliser - Warwick Spinal Immobiliser - Development and Initial Trial of Prototype Spinal Immobilisation Device | In Set-Up Pending NHS Permission | Observational | No |
| | WEIGHTED - Weight Estimation Intended to Guide How to Dose Treatment in the Emergency Department | Open | Observational | No |
| | WHiTE One - The Warwick Hip Trauma Evaluation One: A randomised controlled trial comparing sliding hip screw and X-Bolt dynamic plate fixation in the treatment of unstable trochanteric fractures of the proximal femur. | Open | Interventional | No |
| 33756652 | WOLLF - A randomised controlled trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients with an open fracture of the lower limb | Open | Interventional | Yes, within lead country only |